FAQ: Can I get off Prednisone if this has been used for many years for Crohn's or colitis? This can be a difficult task. The main objective will be to drugs that can replace the effect of steroids. Typically this will be azathioprine or adalimumab. It can be helpful to use Entocort a non-absorbed steroid for a few 6-12 months while slowly reducing Prednisone by 1mg per month. The critical period is reducing from Prednisone 5mg.