FAQ: Is it safe to use Loperamide long-term for management of diarrhoea

Yes. This is a very safe and highly effective treatment for diarrhoea but the cause of the diarrhoea should be investigated before starting long term treatment

The commonest indication is for diarrhoea-predominant irritable bowel syndrome where there is urgency of bowel habit and fear of incontinence. One or two capsules of loperamide daily can significantly improve quality of life. Sometimes in IBS there is sensitivity to the action of loperamide and only small doses are required. In this situation the tablet needs to be prescribed so that only half tablet can be taken daily